Identification of a Novel Lipoprotein Regulator of Clostridium difficile Spore Germination.
Clostridium difficile is a Gram-positive spore-forming pathogen and a leading cause of nosocomial diarrhea.C.difficile infections are transmitted when ingested spores germinate in the gastrointestinal tract and transform into vegetative cells.Germination begins when the germinant read more receptor CspC detects bile salts in the gut.CspC is a subti